Mots C
 
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by the 12S rRNA region of the mitochondrial genome. It has garnered significant interest for its potential health benefits, particularly in metabolic regulation, aging, and physical performance.
Improved Insulin Sensitivity and Glucose Metabolism: MOTS-c enhances insulin sensitivity and glucose uptake in skeletal muscle via the AMPK pathway, mimicking exercise effects. It prevents diet-induced and age-related insulin resistance in mice, with potential benefits for type 2 diabetes management.
Enhanced Fat Loss and Lipid Metabolism: MOTS-c promotes fat breakdown (lipolysis) and reduces fat accumulation by boosting energy expenditure and fat “browning.” Mouse studies show it prevents obesity, and anecdotal human reports suggest midsection fat loss.
Anti-Aging and Physical Performance: MOTS-c improves mitochondrial function, boosting energy and physical capacity. In mice, it doubled running capacity in older age groups and extended healthy lifespan, while human studies show increased MOTS-c levels post-exercise, supporting endurance and recovery.