A copper-binding tripeptide (glycyl-L-histidyl-L-lysine), offers multiple health and cosmetic benefits, primarily due to its regenerative, anti-inflammatory, and antioxidant properties. Its levels in the body decline with age, contributing to reduced tissue repair and signs of aging. Below are the key benefits, supported by research:
Skin Rejuvenation and Anti-Aging
Stimulates Collagen and Elastin Production: GHK-Cu promotes the synthesis of collagen and elastin, essential for skin firmness and elasticity. Clinical studies show it increases skin density, thickness, and reduces fine lines and wrinkles when applied topically for 12 weeks.
Improves Skin Texture and Appearance: It reduces photodamage, hyperpigmentation, and mottled pigmentation, enhancing skin clarity and smoothness. A 12-week study on 71 women with photoaged skin confirmed reduced laxity and improved clarity.
Enhances Skin Elasticity: GHK-Cu increases glycosaminoglycan synthesis, improving skin hydration and elasticity. It outperforms vitamin C and retinoic acid in boosting collagen production in 70% of users.
Reduces Scars and Inflammation: By modulating metalloproteinases and their inhibitors, it aids in tissue remodeling, reducing scar visibility and supporting skin repair.
 
Wound Healing
Accelerates Tissue Repair: GHK-Cu promotes wound contraction, angiogenesis (new blood vessel formation), and the migration of fibroblasts and keratinocytes, crucial for healing. It has shown efficacy in diabetic and ischemic wounds in animal models.
Antioxidant and Anti-Inflammatory Effects: It reduces oxidative stress and inflammatory cytokines (e.g., TNF-α, IL-6), protecting tissues post-injury and enhancing healing. Pretreatment with GHK-Cu lowered ROS levels by up to 60% in cells exposed to hydrogen peroxide.
 
Hair Growth
Stimulates Hair Follicles: GHK-Cu enhances microcirculation, boosts follicle cell proliferation, and extends the anagen (growth) phase of hair. Studies suggest it matches or exceeds the efficacy of 5% minoxidil for hair regrowth.
Improves Hair Thickness: By supporting collagen and elastin in the scalp, it strengthens hair and reduces thinning, with users reporting thicker, healthier hair.
 
Systemic and Neurological Benefits
Neuroprotection and Cognitive Health: GHK-Cu crosses the blood-brain barrier, promoting nerve regeneration, increasing nerve growth factors, and potentially reversing cognitive decline in aging mice. It may hold promise for neurodegenerative disorders like Alzheimer’s.